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《医学前沿(英文)》 2023年 第17卷 第3期 页码 549-561 doi: 10.1007/s11684-022-0965-7
关键词: pregnancy IgG glycome type I interferon systemic lupus erythematosus
Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 480-489 doi: 10.1007/s11684-017-0594-8
Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I (HIV-1). Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design.
关键词: human immunodeficiency virus type I superinfection incidence immune response
High-expression of recombinant human concensus interferon-α by Pichia pastoris
HAO Yuyou, SHI Qiqi, HE Yun, ZHUANG Yingping, WANG Yonghong, ZHANG Siliang, CHU Ju, LIU Zhimin
《化学科学与工程前沿(英文)》 2007年 第1卷 第4期 页码 399-403 doi: 10.1007/s11705-007-0073-x
通过<i> B i>位Ta置换对<i> AB i> O4型EuNbO4的热学和力学性质进行优化 Article
陈琳, 冯晶
《工程(英文)》 2020年 第6卷 第2期 页码 177-184 doi: 10.1016/j.eng.2019.12.006
铁弹性的ABO4型RETaO4陶瓷和RENbO4陶瓷(RE表示稀土)是具有潜在应用价值的热障涂层(TBC)材料,研究人员正在对其进行大量研究。结果显示, RETaO4陶瓷的力学性质优于RENbO4陶瓷的力学性质。在本研究中,我们通过B位钽(Ta)置换对利用固相法(SSR)制备的EuNbO4陶瓷的热学和力学性质进行优化。我们使用X射线衍射(XRD)法和拉曼光谱技术对所制备的晶体结构进行确认,并利用扫描电子显微镜(SEM)对结构表面的微观形貌进行观察。结果表明,通过B位Ta置换可以有效提高EuNbO4陶瓷的杨氏模量和热膨胀系数(TEC),且其最大值分别为169 GPa和1.12×10−5 K−1(1200 ℃); EuNbO4陶瓷的热导率被降低至1.52 W·K–1·m–1(700 ℃),且材料的抗热辐射能力得到了改善。我们建立了声子热扩散系数与温度之间的关系,用以通过消除热辐射效应来确定声子本征热导率。研究结果表明,通过B位Ta置换能够有效优化EuNbO4的热学和力学性质,从而使得此种材料在将来可成为一种高温结构陶瓷材料。
Phase separation in cGAS-STING signaling
《医学前沿(英文)》 页码 855-866 doi: 10.1007/s11684-023-1026-6
关键词: biomolecular condensates phase separation cGAS-STING pathway cGAS STING cGAMP interferon
New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation
《医学前沿(英文)》 2022年 第16卷 第1期 页码 17-24 doi: 10.1007/s11684-021-0873-2
Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang
《医学前沿(英文)》 2019年 第13卷 第2期 页码 238-249 doi: 10.1007/s11684-017-0599-3
关键词: interferon-α hematopoietic stem cell transplantation minimal residual disease donor lymphocyte infusion
Personalized medicine of type 2 diabetes
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 1-3 doi: 10.1007/s11684-013-0241-y
Metabolomics in human type 2 diabetes research
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 4-13 doi: 10.1007/s11684-013-0248-4
The high prevalence of diabetes and diabetic complications has caused a huge burden on the modern society. Although scientific advances have led to effective strategies for preventing and treating diabetes over the past several decades, little progress has been made toward curing the disease or even getting it under control, from a public health and overall societal standpoint. There is still a lack of reliable biomarkers indicative of metabolic alterations associated with diabetes and different drug responses, highlighting the need for the development of early diagnostic and prognostic markers for diabetes and diabetic complications. The emergence of metabolomics has allowed researchers to systemically measure the small molecule metabolites, which are sensitive to the changes of both environmental and genetic factors and therefore, could be regarded as the link between genotypes and phenotypes. During the last decade, the progression made in metabolomics has provided insightful information on disease development and disease onset prediction. Recent studies using metabolomics approach coupled with statistical tools to predict incident diabetes revealed a number of metabolites that are significantly altered, including branched-chain and aromatic amino acids, such as isoleucine, leucine, valine, tyrosine and phenylalanine, as diagnostic or highly-significant predictors of future diabetes. This review summarizes the current findings of metabolomic studies in human investigations with the most common form of diabetes, type 2 diabetes.
关键词: metabolomics type 2 diabetes metabolic pathway mass spectrometry nuclear magnetic resonance (NMR)
《结构与土木工程前沿(英文)》 2021年 第15卷 第4期 页码 1071-1071 doi: 10.1007/s11709-021-0736-6
The mechanisms linking adiposopathy to type 2 diabetes
null
《医学前沿(英文)》 2013年 第7卷 第4期 页码 433-444 doi: 10.1007/s11684-013-0288-9
Obesity is defined as excessive accumulation of body fat in proportion to body size. When obesity occurs, the functions of adipose tissue may be deregulated, which is termed as adiposopathy. Adiposopathy is an independent risk factor for many diseases, including diabetes and cardiovascular diseases. In overweight or obese subjects with adiposopathy, hyperlipidemia exerts lipotoxicity in pancreatic islet and liver and induces pancreatic β cell dysfunction and liver insulin resistance, which are the decisive factors causing type 2 diabetes. Moreover, adipokines have been shown to play important roles in the regulation of glucose homeostasis. When adiposopathy occurs, abnormal changes in the serum adipokine profile correlate with the development and progression of pancreatic β cell dysfunction and insulin resistance in peripheral tissue. The current paper briefly discusses the latest findings regarding the effects of adiposopathy-related lipotoxicity and cytokine toxicity on the development of type 2 diabetes.
Mechanical performance analysis and stiffness test of a new type of suspension bridge
《结构与土木工程前沿(英文)》 2021年 第15卷 第5期 页码 1160-1180 doi: 10.1007/s11709-021-0760-6
关键词: new type of suspension bridge stiffness test mechanical performance railway bridge space truss
Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects
Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao
《医学前沿(英文)》 2019年 第13卷 第4期 页码 427-437 doi: 10.1007/s11684-018-0672-6
关键词: targeted therapy desmoid-type fibromatosis tyrosine kinase inhibitor γ-secretase inhibitor
Development of an axial-type fan with an optimization method
Chong-hyun CHO, Soo-yong CHO, Chaesil KIM,
《能源前沿(英文)》 2009年 第3卷 第4期 页码 414-422 doi: 10.1007/s11708-009-0038-5
关键词: axial-type fan gradient method free-vortex method design variable total pressure static pressure operating flowrate
Qing YE, Donghui LI, Jun ZHAO, Jiansheng ZHAO, Tianfang KANG, Shuiyuan CHENG
《环境科学与工程前沿(英文)》 2011年 第5卷 第4期 页码 497-504 doi: 10.1007/s11783-011-0256-z
关键词: 13X-type zeolite CO oxidation gold solution pH calcination temperature
标题 作者 时间 类型 操作
Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions
期刊论文
Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:
null
期刊论文
High-expression of recombinant human concensus interferon-α by Pichia pastoris
HAO Yuyou, SHI Qiqi, HE Yun, ZHUANG Yingping, WANG Yonghong, ZHANG Siliang, CHU Ju, LIU Zhimin
期刊论文
Interferon-α salvage treatment is effective for patients with acute leukemia/myelodysplastic syndrome
Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang
期刊论文
Correction to: Effect of wood dust type on mechanical properties, wear behavior, biodegradability, and
期刊论文
Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects
Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao
期刊论文
Development of an axial-type fan with an optimization method
Chong-hyun CHO, Soo-yong CHO, Chaesil KIM,
期刊论文